The APAF-1-ALT Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to APAF1. This antibody recognizes Human antigen. The APAF-1-ALT Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.Keigo Machida, J. Biol. Chem., Apr 2001; 276: 12140 - 12146.Liam O¡¯Connor, Cancer Res., Mar 2000; 60: 1217 - 1220.Zeping Wang, Nucleic Acids Res., Apr 2005; 33: 2248 - 2258Govindaraj Anumanthan, Cancer Res., Nov 2006; 66: 10824 - 10832